Basically you want to run the coldest plug you can without fouling. This will minimize any chance of pinging and the resultant loss of timing due to the knock sensors telling the PCM to back down the advance.
Start with the 764s. Next change, if there is no suggestion of plug fouling upon inspection of the spark plugs, go with a one step colder plug such as the AWSF 22c's. After that you can try the 12c's, but be wary of any mis-fires that may suggest fouling of the sparkplugs, especially on a typical stock 'uber-rich' tune (Tommy coined that term).
Your experience will vary according to the vehicle and driver. Typically with a stock Mark VIII, no benefit will be gained from a colder plug.