The valves aren't held opened. They are held closed. And you don't need fuel to have a misfire. Ever have a dead injector? Or a collapsed intake lifter? Both of those things will prevent fuel from entering the combustion chamber, and will create a misfire. The definition of a misfire is not firing at the wrong time, but when a problem prevents that cylinder from making power after it has used energy to compress air. If the valves are held closed, then there is no air to compress, and the piston rings will not seal well, so it will take hardly any work to turn that cylinder over. If you leave the valves operating as normal, but cut fuel and spark from a cylinder, you still have to do all the work to keep 8 cylinders running, only now instead of getting some of that work back from each of the 8 cylinders, you are only getting some of it back from 4. The result is that it is less efficient, and will get you worse gas mileage. If you don't believe me, try it yourself. Unplug half your injectors, leaving 2 pairs of cylinders that are 180 crankshaft degrees from each other, and try driving it around like that and see how many miles a tank of gas lasts. Plain and simple, it doesn't work without the valvetrain mods. If you can figure out a way to disable the valves at the same time as the injectors, then you can make it work, but that is far more complicated than just disabling injectors, and without it you will only hurt your mileage.