How does the engine sound? Any loud knocks or ticks? Are the accessories making any groans or whines? How does the serpentine belt look? Has the tensioner been replaced since you turned over 100k? What are your maintenance habits like? When were all of the fluids changed last? Trans fluid, diff fluid, engine coolant? If you've kept up with regular preventive maintenance items, you should be just fine. But if it's been neglected in the past it may be time to trade it in for something newer, or at least with lower miles.
Its hard to tell sometimes when something is getting ready to break down unless you've dealt with problems in the past that may now be exhibiting symptoms of wear or potential failure again. If you're unsure of anything, or there is anything that has caught your attention recently, or even if there isn't, it might be wise to take it to a shop and have it inspected for potential problems.