Royal Purple, Amsoil, and Redline are the only "true" synthetics left on the market, that is, they are made from PAOs. The other synthetics are hydrocracked petroleum, which still outperforms conventional dino oils, but they are basically uber-refined dino oil which is not truly a synthetic.
With RP in my engine, trans, and diff I can't really attest to any benefit in track times or horsepower, I can verify about a 1mpg increase, and I have the peace of mind in knowing I have the best stuff available. RP PS fluid actually made a hell of a lot of noise in my pump, so I just switch to Mobil1 ATF and it works just fine. For coolant, I use the Low-Tox green stuff with Red Line Water Wetter, but I will be moving to RP's Ice stuff because it contains more corrosion inhibitors than Water Wetter.
In the big scheme of things, Motorcraft's lubricants will work just fine on anything that is close to stock and not track driven, but I am just anal retentive about that stuff.