Possible, but not likely very accurate. It would depend a lot on road conditions (was the 5mi of road on a downhill trend or was it even). Think of it this way... it is possible to shift into N and let the car coast down a hill at 55 mph and get wonderfull gas mileage, but this is not practicle. The time you spent getting that 30 mpg (~5min) is going to be greatly outweighed by the time you spend getting less (or zero) miles per gallon. That is why average is really the only number that matters. And the greater time that is in that average the less volitle (prone to change) the average number will be.
Do this. Fill your tank, reset your computer, run it to empty (or 1/4 whichever you prefer), fill your tank, then check your average by hand vs. what the computer reads. They should be close (within 1mpg) but not exact.
These averages will change depending on how you drove those miles.
For example: I recently took a weekend trip to see my girl. Filled up by my house, drove 200 miles on the highway with cruse set at 75, filled up when I got off the highway. I checked my mpg (miles driven/gallons added) and got 26.4 I typically get 18 in the city and 24-26 highway so this was right on what I expected.
hope this helps.
n8