Gee Frogman, what a helpful response that was.  We're all so glad you took time out of your busy day to post that. 
 
 
Anyway for E85 you will need a tune.  This isn't a kind of tune you can mail order either, you'll need somebody with experience and a wideband at minimum.  E85 eats rubber, so eventually anything in your fuel system made of rubber will disintegrate and need replacement with alternative materials.  You may see a reduction in fuel economy of around 25% on E85 compared to gasoline because of the lower energy content of ethanol.  You may end up running your injectors at a high (80% or more) duty cycle, which means you may end up requiring higher flowing injectors.  You should see a slight (>5%) increase in power on E85 over premium gasoline with a good tune because it'll allow more timing.