Get a new PCV valve and hose, you can only change them with all of the manifold and fuel injector package off.
Go ahead and plug your coolant lines at the end of the hoses where they come off the throttle body, most definitely. I used bolts for mine, 5/16" longer bolts without thread all the way to the head, allows for a clean seal while it's apart.
Watch the bolts for the shock tower brace, you have 2 on each side and three in the middle of the firewall. They have a tendency to shear off from corrosion, if you live in a salt belt (for winter precip) area. Be prepared to drill out the old bolts and tap threads for new ones. Don't put it back together without all 7 bolts firmly in place.
You may also need to remove the harness hold downs on the body near the pass side rear of the cylinder head, to allow better manipulation of the connectors that you have to undo. That large 20-pin (approx) connector can be a real biotch to get apart and can drain some serious time off your hands while you "richard" with it.
Use a quality torque wrench for the plenum bolts, they only require a small amount of torque and you could easily over-tighten them.
After you do this, if it has never been done to that car, you should see increased low-rpm torque and 1-2 mpg better fuel economy for a while.
Enjoy your V6!